Isolated Hexomino Pair Rectangles
The starting point for this investigation is George Sicherman’s Hexomino Pair Rectangles. In that page, he defines a hexomino pair rectangle as a rectangle that can be tiled by a pair of hexominoes using at least one of each. I add a constraint - hexominoes from one of the pair are not allowed to touch. I refer to the hexominoes as the isolating, and isolated hexomino.
In the table below, you will see number of tiles needed to for each pair of hexominoes. The rows are the isolating hexominoes, while the columns are the isolated hexomino. The tilings are minimal to the best of my knowledge. If you find a solution with less tiles, or a new solution, please write.
Contributions were received from George Sicherman (GS).
Hexomino Numbers

Table of Results
In the table, the entries are the number of tiles needed, which are then referenced in the list of tilings below. Round brackets indicate that this tiling was already isolated in Hexomino Pair Rectangles, so refer back to that page to see the tiling. Spaces in the table may indicate that a tiling is possible or impossible. Refer to Hexomino Pair Rectangles to understand which.

3 Tiles

4 Tiles

5 Tiles

6 Tiles

7 Tiles

8 Tiles

9 Tiles

10 Tiles

12 Tiles

14 Tiles

15 Tiles

16 Tiles

18 Tiles

20 Tiles

21 Tiles

22 Tiles

24 Tiles

25 Tiles

26 Tiles

28 Tiles

30 Tiles

32 Tiles

34 Tiles

35 Tiles

36 Tiles

39 Tiles

40 Tiles

42 Tiles

44 Tiles

46 Tiles

48 Tiles

50 Tiles

52 Tiles

54 Tiles

56 Tiles

60 Tiles

64 Tiles

65 Tiles

66 Tiles

68 Tiles

70 Tiles

72 Tiles

76 Tiles

78 Tiles

84 Tiles

90 Tiles

92 Tiles

96 Tiles

98 Tiles

112 Tiles

116 Tiles

120 Tiles

128 Tiles

140 Tiles

168 Tiles

260 Tiles

320 Tiles

1368 Tiles
